STRUKTUR HISTOLOGI HATI TIKUS PUTIH (Rattus norvegicus Berkenhout 1769) DENGAN PEMBERIAN RAMUAN TRADISIONAL MASYARAKAT MELAYU LINGGA, KEPULAUAN RIAU

  • Fitmawati Fitmawati Jurusan Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riau, Pekanbaru, Indonesia
  • Titrawani Titrawani Jurusan Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riau, Pekanbaru, Indonesia
  • Welly Safitri Jurusan Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riau, Pekanbaru, Indonesia

Abstract

Lingga Island is the center of the Malay kingdom of Kepulauan Riau Province with local wisdom that is still ingrained in the community. Obat pahit is a decoction of linguistic stew of ethnic lingga community which is believed to be a youthful remedy and maintain stamina. This study aims to find histopathologic changes of liver white mice after the decoction of herb concoction of Obat pahit. The percentage of intercellular damage was nonexistent from the normal control group and positive control but different from the negative control group. Different types of medicinal herbs with different dosage levels.  But the damage is still in the normal, accessible category that has no toxic effects from bitter herbs on liver organ.

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References

Arsad S.S., Esa N.M. and Hamzah H. 2014. Histopathologic Changes in Liver and Kidney Tissues from Male Sprague Dawley Rats Treated with Rhaphidophora Decursiva (Roxb.) Schott Extract. Journal of Cytology & Histology. S4: 001. doi: 10.4172/2157-7099.S4-001.

Baldatina A.Z.I. 2008. Pengaruh Pemberian Insektisida (Esbiothrin, Imiprothrin dan D-Phenothrin) pada Tikus Putih (Rattus rattus): Kajian Histopatologi Hati dan Ginjal. Fakultas Kedokteran Hewan. Institut Petanian Bogor. Bogor.

Cheville N.F. 1999. Introduction to Veterinary Pathology. USA: Lowa State University Press.

Dannuri H. 2009. Analisis Enzim Alanin Amino Tranferase (ALAT), Aspartat Amino Transferase (ASAT), Urea Darah, dan Histopatologis Hati dan Ginjal Tikus Putih Galur Sprague-Dawley Setelah Pemberian Angklak. J Teknol dan Industri Pangan 20(1):1-9.

Fitmawati, Sofiyanti N., Roza R.M., Isnaini, Hazimi H., Irawan Y.R., Winata D.R. and Dewi A.P.K. 2017. Traditional medicinal formulation: Obat pahit from Lingga Malay Ethnic in Riau Archipelago, Indonesia. Biodiversitas. 18(3): 1196-1200.

Fortes R.C. 2017. Nutritional Implications in Chronic Liver Diseases. Journal of Liver Research, Disorders & Therapy. 3(5). 00071. DOI: 10.15406/jlrdt.2017.03.0007.

Junqueira L.C. Carneiro J. 2007. Histologi Dasar. Jakarta: EGC.

Kurniawan W.A.Y., Ngurah I.W. dan Ni W.S. 2014. Histologi hati mencit (Mus musculus l.) yang diberi ekstrak daun lamtoro (Leucaena leucocephala). Jurnal Simbiosis II (2):226-235

Lailatul N.F., Diana L.Y. dan Mudjiwijono H. 2015. Efek pemberian asam alfa lipoat terhadap kadar MDA dan gambaran histologi pada hati tikus model diabetes melitus tipe 1. Jurnal Kedokteran Brawijaya. 28(3):170-177

Lawrance D.R. and Bacharach A.I. 1964. Evaluation of Drug Ativities: Pharmacometric. New York: Academic Press.

Lu F.C. 1995. Toksikologi Dasar; Asas,Organ Sasaran, dan Penilaian Resiko. Edisi ke-2.Penerbit Universitas Indonesia. Jakarta: UI Press.

Marianne P.T., Litiele C., Jeferson L.F., Renara B.V. and Valdir M.S. 2016. Ethnobotany and antioxidant evaluation of commercialized medicinal plants from the Brazilian Pampa. Acta Botanica Brasilica 30(1):47-59.

Niranjan R. 2016. Liver. Journal of Liver. 5 (3). DOI: 10.4172/2167-0889.1000e112.

Ozougwu J. 2017. Physiology of the liver. International Journal of Research in Pharmacy and Biosciences. 4(8):13-24.

Robbins S.L., Cotran R.S. dan Kumar V. 2007. Jejas Adaptasi dan Kematian Sel. Dalam: Buku Ajar Patologi I. Jakarta: EGC.

Sujono T.A., Arifah S.R. Muhammad D., Ika T.D.K., Andi S., Rima M., Nanik P., Saidatul F., Riya R. dan Siti L. 2015. Pengaruh pemberian ekstrak etanol meniran (phyllanthus niruri l) selama 90 hari terhadap fungsi hati tikus. University Research Colloquium. 136-142

Tatukude P., Lily L. dan Poppy L. 2014.Gambaran histopatologi hati mencit swiss yang diberi air rebusan sarang semut (Mymercodia pendans) paska induksi dengan carbon tetrachlorida (CCL4). Jurnal e-Biomedik (Ebm). 2(2):459-466.

Westbrook R.H., Dusheiko G. and Williamson. 2016. Pregnancy and Liver Disease. Journal of Hepatology. 64:933-945.

Wicaksono H.S., Inna N. dan Iriani S. 2015.Struktur hati mencit (Mus musculus l.) Setelah pemberian ekstrak daun kaliandra merah (Calliandra calothyrsus meissn) Jurnal simbiosis III. (1):258-268.

Published
2019-01-02
How to Cite
Fitmawati, F., Titrawani, T., & Safitri, W. (2019). STRUKTUR HISTOLOGI HATI TIKUS PUTIH (Rattus norvegicus Berkenhout 1769) DENGAN PEMBERIAN RAMUAN TRADISIONAL MASYARAKAT MELAYU LINGGA, KEPULAUAN RIAU. EKOTONIA: Jurnal Penelitian Biologi, Botani, Zoologi Dan Mikrobiologi, 3(1), 11-19. https://doi.org/10.33019/ekotonia.v3i1.753
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